A caffeine containing weight loss supplement augments hemodynamic responses after exercise

source extracted confidence: high 2026-04-09
#adolescent #adult #blood-pressure #caffeine #cross-over-studies

A caffeine containing weight loss supplement augments hemodynamic responses after exercise

Buchanan et al., 2018 | Int J Cardiol | Rct

Citation

Buchanan S R, Karabulut M. A caffeine containing weight loss supplement augments hemodynamic responses after exercise. Int J Cardiol. 2018-Feb-15;253:133-137. doi:10.1016/j.ijcard.2017.11.012

Abstract

BACKGROUND: Since the effects of supplements can be potentially harmful and/or ineffective to obtain desired positive benefits, there is a need to investigate supplementation to understand the responses of physiological systems, to educate consumers, and to provide feedback for businesses creating these supplements. The purpose of the current study was to test hemodynamic responses of a weight loss supplement and determine its effects on hemodynamic variables. METHODS: 31 participants underwent a randomized, double-blind, crossover study design and received a placebo or supplement on two separate days. Baseline measures of all variables were assessed prior to exercise. During exercise, each participant performed treadmill running at 80% VO2PEAK until volitional fatigue. Immediately post-exercise, hemodynamic measures were recorded at multiple time points. RESULTS: There was a significant condition∗time interaction with the supplement having a higher PWV for the carotid to femoral segment (p=0.004). There were also significant condition∗time interactions for heart rate (p=0.001). Large arterial elasticity was significantly lower for the supplement (p=0.005). Systolic blood pressure was conditionally higher (p=0.001), as was diastolic blood pressure (p=0.003) and mean arterial pressure (p=0.003). Vascular resistance was conditionally higher for the supplement (p=0.044). CONCLUSIONS: Ingredients in the supplement caused multiple negative effects within hemodynamics and were ineffective at increasing running time.

Key Findings

There was a significant condition∗time interaction with the supplement having a higher PWV for the carotid to femoral segment (p=0.004). There were also significant condition∗time interactions for heart rate (p=0.001). Large arterial elasticity was significantly lower for the supplement (p=0.005). Systolic blood pressure was conditionally higher (p=0.001), as was diastolic blood pressure (p=0.003) and mean arterial pressure (p=0.003). Vascular resistance was conditionally higher for the suppleme

Outcomes Measured

  • blood pressure
  • systolic blood pressure
  • diastolic blood pressure

Population

Field Value
Population See abstract
Sample Size 31
Age Range See abstract
Condition blood pressure

MeSH Terms

  • Adolescent
  • Adult
  • Blood Pressure
  • Caffeine
  • Cross-Over Studies
  • Dietary Supplements
  • Double-Blind Method
  • Exercise
  • Female
  • Hemodynamics
  • Humans
  • Male
  • Pulse Wave Analysis
  • Vascular Resistance
  • Weight Loss
  • Young Adult

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: caffeine

Provenance

Source extracted via PubMed E-utilities API on 2026-04-10