[Effect of Panax notoginseng preparations on platelet function]

source extracted confidence: high 2026-04-09
#blood-platelets #drugs-chinese-herbal #hemorrhage #humans #panax-notoginseng

[Effect of Panax notoginseng preparations on platelet function]

Li et al., 2017 | Zhongguo Zhong Yao Za Zhi | Meta Analysis

Citation

Li Yue, Yang Feng-Wen, ... Zhang Jun-Hua. [Effect of Panax notoginseng preparations on platelet function]. Zhongguo Zhong Yao Za Zhi. 2017-Nov;42(21):4226-4233. doi:10.19540/j.cnki.cjcmm.20170901.004

Abstract

To systematically evaluate the effect of Panax notoginseng preparations (PNPs) on platelet function six literature databases including PubMed, EMbase, the Cochrane Library, CNKI, WanFang, and SinoMed were searched to collect RCTs of PNPs. RCTs reporting the outcomes of platelet function could be included. Biases were evaluated by Cochrane handbook. Two reviewers screened literature, extracted data and assessed the risk of bias of included studies independently. Inconsistency were solved by discussion.Meta-analysis was conducted by RevMan 5.3 software.A total of 36 RCTs were involved with the outcome including MPAR, PLT, TXB2 and safety. The results of systematic review showed that compared with placebo [SMD=1.84,95%CI(1.33,2.35),P<0.000 01] and non-antiplatelet agents [SMD=0.74,95%CI(0.19,1.28),P=0.008] PNPs can reduce the MPAR level; PNPs combined with non-antiplatelet agents can reduce MPAR [SMD=2.34,95%CI(1.14,3.54),P=0.000 1] and TXB2(SMD=1.25,95%CI(0.75,1.76),P<0.000 01]; PNPs combined with anti-platelet agents have better effect on MPAR [SMD=0.93,95%CI(0.58,1.29),P<0.000 01] and TXB2 [SMD=1.16,95%CI(0.74,1.58),P<0.000 01]. In terms of hemorrhagic adverse reactions, PNPs combined with anti-platelet agents haven't increase adverse events. Current evidences suggested that PNPs can reduce MPAR level and TXB2. PNPs combined with anti-platelet or non-antiplatelet agents can improve efficacy. However, due to the huge clinical heterogeneity and poor methodological quality, the evidence is not strng enough. Rigorous designed clinical trials are warranted.

Key Findings

Rigorous designed clinical trials are warranted.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 36
Age Range See abstract
Condition See abstract

MeSH Terms

  • Blood Platelets
  • Drugs, Chinese Herbal
  • Hemorrhage
  • Humans
  • Panax notoginseng
  • Randomized Controlled Trials as Topic

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: ginseng

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09