Vitamin D ratio and glycaemic control in individuals with type 2 diabetes mellitus: A systematic review

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#diabetes-mellitus-type-2 #humans #hyperglycemia #hypoglycemia #vitamin-d

Vitamin D ratio and glycaemic control in individuals with type 2 diabetes mellitus: A systematic review

Santos et al., 2018 | Diabetes Metab Res Rev | Systematic Review

Citation

Santos Ramara Kadija Fonseca, Brandão-Lima Paula Nascimento, ... Pires Liliane Viana. Vitamin D ratio and glycaemic control in individuals with type 2 diabetes mellitus: A systematic review. Diabetes Metab Res Rev. 2018-Mar;34(3). doi:10.1002/dmrr.2969

Abstract

Several studies have suggested a favorable role for vitamin D in glycaemic metabolism and its potential as adjuvant treatment of type 2 diabetes mellitus. This review discusses the role of vitamin D in the glycaemic control of individuals with type 2 diabetes mellitus and evaluates the effect of vitamin D supplementation on glycaemic markers in this population. Literature searches were performed in the BIREME, LILACS, and PubMed databases using the Medical Subject Headings and words related to vitamin D, type 2 diabetes mellitus, and glycaemic control. Interventional and observational studies were considered eligible. The evaluation of the included studies was independently performed by 2 evaluators at all stages of selection, data extraction, and bias risk assessment. The primary outcome was the relationship between vitamin D levels and glucose metabolism markers in type 2 diabetes mellitus individuals. The secondary outcome was the effect of vitamin D supplementation on the glycaemic control markers in individuals with type 2 diabetes mellitus. The inverse relationship between vitamin D and variables of glucose metabolism was verified. Interventional studies revealed that vitamin D supplementation did not alter glycaemic control markers in most studies. Few studies have shown positive effects with a significant reduction in the percentage of glycated haemoglobin, insulin, and glucose concentrations, and changes in homeostatic model assessment-insulin resistance and beta cell, and quantitative insulin sensitivity check index. Therefore, despite the association of vitamin D with glucose metabolism, there is insufficient evidence of the beneficial effects of its supplementation on the metabolic control of type 2 diabetes mellitus.

Key Findings

Therefore, despite the association of vitamin D with glucose metabolism, there is insufficient evidence of the beneficial effects of its supplementation on the metabolic control of type 2 diabetes mellitus.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population type 2 diabetes mellitus
Sample Size See abstract
Age Range See abstract
Condition diabetes

MeSH Terms

  • Diabetes Mellitus, Type 2
  • Humans
  • Hyperglycemia
  • Hypoglycemia
  • Vitamin D
  • Vitamins

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: vitamin-d-diabetes

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09