Chromium Supplementation Reduces Resting Heart Rate in Patients with Metabolic Syndrome and Impaired Glucose Tolerance

source extracted confidence: high 2026-04-09
#chromium #dna-damage #double-blind-method #glucose-intolerance #heart-rate

Chromium Supplementation Reduces Resting Heart Rate in Patients with Metabolic Syndrome and Impaired Glucose Tolerance

Nussbaumerova et al., 2018 | Biol Trace Elem Res | Rct

Citation

Nussbaumerova Barbora, Rosolova Hana, ... Sindberg Christian. Chromium Supplementation Reduces Resting Heart Rate in Patients with Metabolic Syndrome and Impaired Glucose Tolerance. Biol Trace Elem Res. 2018-Jun;183(2):192-199. doi:10.1007/s12011-017-1128-6

Abstract

Chromium (Cr) is considered as an important mineral, involved in biochemical reactions in human metabolic pathways. Organically bound Cr supplementation has been suggested to improve glycemia especially in patients with type 2 diabetes mellitus, but there are conflicting reports on efficacy. Effect of Cr is not clear in prediabetes status. Seventy patients with metabolic syndrome and impaired glucose tolerance (IGT), who are observed and treated in the Center of Preventive Cardiology of the University Hospital in Pilsen, were included in the prospective, randomized, double-blind, and placebo-controlled clinical study. Effect of Cr-enriched yeast (200 μg of elementary Cr in the morning and 100 μg in the evening) on glucose, lipid metabolism, fat tissue hormones, oxidative stress, and DNA damage markers was analyzed. There were no significant changes in glucose and lipid parameters, oxidative stress, or other laboratory markers. Only resting heart rate was significantly reduced in patients treated by Cr yeast, reflecting reduced sympathetic activity. This could represent an important cardiovascular risk reduction in patients with high cardiometabolic risk.

Key Findings

This could represent an important cardiovascular risk reduction in patients with high cardiometabolic risk.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population type 2 diabetes mellitus
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Chromium
  • DNA Damage
  • Double-Blind Method
  • Glucose Intolerance
  • Heart Rate
  • Humans
  • Lipid Metabolism
  • Metabolic Syndrome
  • Oxidative Stress
  • Prospective Studies

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: chromium-blood-sugar

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09