Effectiveness of n-3 fatty acids in the treatment of hypertriglyceridemia in HIV/AIDS patients: a meta-analysis

source extracted confidence: high 2026-04-09
#acquired-immunodeficiency-syndrome #anti-hiv-agents #fatty-acids-omega-3 #hiv-infections #humans

Effectiveness of n-3 fatty acids in the treatment of hypertriglyceridemia in HIV/AIDS patients: a meta-analysis

Vieira et al., 2017 | Cien Saude Colet | Meta Analysis

Citation

Vieira Aline Doria Sobral, Silveira Glória Regina Mesquita da. Effectiveness of n-3 fatty acids in the treatment of hypertriglyceridemia in HIV/AIDS patients: a meta-analysis. Cien Saude Colet. 2017-Aug;22(8):2659-2669. doi:10.1590/1413-81232017228.21752015

Abstract

Hypertriglyceridemia is common in antiretroviral therapy-treated patients and Omega 3 fatty acids are being used as a intervention in reducing serum triglycerides (TG) in these patients. The objective of this study is to evaluate the effectiveness of the use of Omega 3 in the treatment of hypertriglyceridemia in HIV/AIDS patients on antiretroviral therapy. This study is a systematic review with meta-analysis of randomized clinical trials. Electronic databases - PubMed, Cochrane and Lilacs were researched. Fifty one articles were encountered. Nine were added to the meta-analysis. The reduction of triglycerides level was -77.55 mg (IC of -121.85 to -33.25) in Omega 3 groups. The analysis considering trials with more than 1000 mg of EPA/DHA included seven studies and the heterogeneity dropped to 0%.The reduction of combined averages was -101.56mg (IC of -145.76 to -57.37). The analysis considering trials with patients that had more than 200 mg/dL of initial triglycerides included also seven trials and the heterogeneity dropped to 0%. The reduction of combined averages was -114.15 mg (IC of -162.34 to -65.97). EPA/DHA supplementation reduces serum triglycerides levels in patients with HIV/AIDS-associated hypertriglyceridemia in stable use of antiretroviral therapy.

Key Findings

EPA/DHA supplementation reduces serum triglycerides levels in patients with HIV/AIDS-associated hypertriglyceridemia in stable use of antiretroviral therapy.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population hiv
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Acquired Immunodeficiency Syndrome
  • Anti-HIV Agents
  • Fatty Acids, Omega-3
  • HIV Infections
  • Humans
  • Hypertriglyceridemia
  • Randomized Controlled Trials as Topic
  • Triglycerides

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: omega-3

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09