Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review

source extracted confidence: high 2026-04-09
#dose-response-relationship-drug #fatty-acid-binding-proteins #humans #molecular-structure #small-molecule-libraries

Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review

Floresta et al., 2017 | Eur J Med Chem | Systematic Review

Citation

Floresta Giuseppe, Pistarà Venerando, ... Rescifina Antonio. Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review. Eur J Med Chem. 2017-Sep-29;138:854-873. doi:10.1016/j.ejmech.2017.07.022

Abstract

Small molecule inhibitors of adipocyte fatty acid binding protein 4 (FABP4) have attracted interest following the recent publications of beneficial pharmacological effects of these compounds. FABP4 is predominantly expressed in macrophages and adipose tissue where it regulates fatty acids (FAs) storage and lipolysis and is an important mediator of inflammation. In the past years, hundreds FABP4 inhibitors have been synthesized for effective atherosclerosis and diabetes treatments, including derivatives of niacin, quinoxaline, aryl-quinoline, bicyclic pyridine, urea, aromatic compounds and other novel heterocyclic compounds. This review provides an overview of the synthesized and discovered molecules as adipocyte fatty acid binding protein 4 inhibitors (FABP4is) since the synthesis of the putative FABP4i, BMS309403, highlighting the interactions of the different classes of inhibitors with the targets.

Key Findings

This review provides an overview of the synthesized and discovered molecules as adipocyte fatty acid binding protein 4 inhibitors (FABP4is) since the synthesis of the putative FABP4i, BMS309403, highlighting the interactions of the different classes of inhibitors with the targets.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition diabetes

MeSH Terms

  • Dose-Response Relationship, Drug
  • Fatty Acid-Binding Proteins
  • Humans
  • Molecular Structure
  • Small Molecule Libraries
  • Structure-Activity Relationship

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: niacin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09