The Role of Polyphenols in Rosacea Treatment: A Systematic Review

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#chalcones #humans #phytotherapy #plant-extracts #polyphenols

The Role of Polyphenols in Rosacea Treatment: A Systematic Review

Saric et al., 2017 | J Altern Complement Med | Systematic Review

Citation

Saric Suzana, Clark Ashley K, ... Lev-Tov Hadar A. The Role of Polyphenols in Rosacea Treatment: A Systematic Review. J Altern Complement Med. 2017-Dec;23(12):920-929. doi:10.1089/acm.2016.0398

Abstract

OBJECTIVES: Various treatment options are available for the management of rosacea symptoms such as facial erythema, telangiectasia, papules and pustules, burning, stinging, and itching. Botanical therapies are commonly used to treat the symptoms. The objective of this review is to evaluate the use of polyphenols in rosacea treatment. DESIGN: PubMed, Embase, Biosis, Web of Knowledge, and Scopus databases were systematically searched for clinical studies evaluating polyphenols in the management of rosacea. RESULTS: Of 814 citations, 6 met the inclusion criteria. The studies evaluated licochalcone (n = 2), silymarin (n = 2), Crysanthellum indicum extract (n = 1), and quassia extract (n = 1). The studies only evaluated topical formations of stated polyphenols. Main results were summarized. CONCLUSIONS: There is evidence that polyphenols may be beneficial for the treatment of rosacea symptoms. Polyphenols appear to be most effective at reducing facial erythema and papule and pustule counts. However, studies included have significant methodological limitations and therefore large-scale, randomized, placebo-controlled trials are warranted to further assess the efficacy and safety of polyphenols in the treatment of rosacea.

Key Findings

Of 814 citations, 6 met the inclusion criteria. The studies evaluated licochalcone (n = 2), silymarin (n = 2), Crysanthellum indicum extract (n = 1), and quassia extract (n = 1). The studies only evaluated topical formations of stated polyphenols. Main results were summarized.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 2
Age Range See abstract
Condition See abstract

MeSH Terms

  • Chalcones
  • Humans
  • Phytotherapy
  • Plant Extracts
  • Polyphenols
  • Rosacea
  • Silymarin

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: milk-thistle

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09