Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis

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#case-control-studies #female #humans #multivariate-analysis #selenium

Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis

He et al., 2017 | Biol Trace Elem Res | Meta Analysis

Citation

He Du, Wang Zaiping, ... Chen Dian. Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis. Biol Trace Elem Res. 2017-Oct;179(2):195-202. doi:10.1007/s12011-017-0982-6

Abstract

Several studies have investigated the relationship between serum Se concentration and cervical cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum selenium levels and cervical cancer. Twelve studies investigating the association by univariate analysis and five studies by multivariate analysis were identified after a systematic search of PubMed, Wanfang, CNKI, and SinoMed databases. Standard mean differences (SMD) or odds ratios (OR) with the corresponding 95% confidence intervals (CI) were pooled to compare the selenium levels between different groups. In univariate analysis, serum selenium levels in cervical cancer cases were significantly lower than in controls (SMD = -4.86, 95% CI -6.03-3.69). Subgroup analysis showed consistent results. In multivariate analysis, serum selenium levels in cervical cancer cases were also significantly lower than in controls (OR = 0.55, 95% CI 0.42-0.73). After treatment, the serum selenium levels increased significantly (SMD = 2.59, 95% CI 0.50-4.69). In conclusion, high serum selenium levels were associated with cervical cancer, and selenium exposure might be a protective factor for cervical cancer.

Key Findings

In conclusion, high serum selenium levels were associated with cervical cancer, and selenium exposure might be a protective factor for cervical cancer.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Case-Control Studies
  • Female
  • Humans
  • Multivariate Analysis
  • Selenium
  • Uterine Cervical Neoplasms

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: selenium-immune

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09