Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis

source extracted confidence: high 2026-04-09
#animals #hypericum #memory #nootropic-agents #placebos

Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis

Ben-Eliezer et al., 2016 | Sci Rep | Meta Analysis

Citation

Ben-Eliezer Daniel, Yechiam Eldad. Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis. Sci Rep. 2016-Oct-20;6:35700. doi:10.1038/srep35700

Abstract

Considered an antidepressant and anti-anxiety agent, Hypericum perforatum affects multiple neurotransmitters in a non-competitive synergistic manner, and may have nootropic potential. We quantitatively reviewed the pre-clinical literature to examine if there is a cognitive-enhancing effect of H. perforatum in healthy rodents. Additionally, within these studies, we compared the effects observed in intact rodents versus those whose performance has been impaired, mostly through stress manipulations. The meta-analysis incorporated studies that examined the effect of H. perforatum versus placebo on memory indices of task performance. All analyses were based on weighting different studies according to their inverse variance. Thirteen independent studies (published 2000-2014) involving 20 experimental comparisons met our inclusion criteria. The results showed a large positive effect of H. perforatum on cognitive performance for intact, healthy rodents (d = 1.11), though a larger effect emerged for stress-impaired rodents (d = 3.10 for restraint stress). The positive effect on intact rodents was observed in tasks assessing reference memory as well as working memory, and was not moderated by the type of memory or motivation (appetitive versus aversive). Thus, while primarily considered as a medication for depression, H. perforatum shows considerable nootropic potential in rodents.

Key Findings

perforatum shows considerable nootropic potential in rodents.

Outcomes Measured

  • anxiety
  • depression

Population

Field Value
Population healthy rodents
Sample Size See abstract
Age Range See abstract
Condition anxiety

MeSH Terms

  • Animals
  • Hypericum
  • Memory
  • Nootropic Agents
  • Placebos
  • Rodentia

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review
  • Vertical: st.-john's-wort

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09