Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

Momtazi et al., 2016 | Mol Diagn Ther | Meta Analysis

Citation

Momtazi Amir Abbas, Derosa Giuseppe, ... Sahebkar Amirhossein. Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases. Mol Diagn Ther. 2016-Aug;20(4):335-45. doi:10.1007/s40291-016-0202-7

Abstract

Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcuma longa. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.

Key Findings

The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.

Outcomes Measured

inflammatory markers

Population

Field	Value
Population	See abstract
Sample Size	See abstract
Age Range	See abstract
Condition	See abstract

MeSH Terms

Animals
Anti-Inflammatory Agents
Antioxidants
Curcumin
Disease Models, Animal
Epigenesis, Genetic
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
Mice
MicroRNAs

Evidence Classification

Level: Meta Analysis
Publication Types: Journal Article, Meta-Analysis, Systematic Review
Vertical: curcumin-cancer

Provenance

PMID: 27241179
DOI: 10.1007/s40291-016-0202-7
PMCID: Not in PMC
Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09