Risk of second primary breast cancer after radioactive iodine treatment in thyroid cancer: a systematic review and meta-analysis

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#breast-neoplasms #humans #iodine-radioisotopes #neoplasms-radiation-induced #neoplasms-second-primary

Risk of second primary breast cancer after radioactive iodine treatment in thyroid cancer: a systematic review and meta-analysis

Zhang et al., 2016 | Nucl Med Commun | Meta Analysis

Citation

Zhang Yingjie, Liang Jun, ... Lin Yansong. Risk of second primary breast cancer after radioactive iodine treatment in thyroid cancer: a systematic review and meta-analysis. Nucl Med Commun. 2016-Feb;37(2):110-5. doi:10.1097/MNM.0000000000000419

Abstract

The aim of this study was to determine whether the risk of second primary breast cancer (SPBC) is increased in thyroid cancer patients treated with radioactive iodine (RAI). We searched the MEDLINE, EMBASE, and the Cochrane Library and Chinese database for studies that reported the risk of SPBC in thyroid cancer patients treated with RAI and patients not treated with RAI. Two independent reviewers screened citations and reviewed full-text papers. A meta-analysis was carried out using the Review Manager software. Six cohort studies (three from Europe, one from America, and two from east Asia) with 17,914 patients were included in this review. The relative risk of SPBC in thyroid cancer survivors treated with RAI was 0.61 (95% confidence interval 0.47-0.79) relative to thyroid cancer survivors not treated with RAI. The risk of SPBC in thyroid cancer survivors treated with RAI is not increased compared with thyroid cancer survivors not treated with RAI.

Key Findings

The risk of SPBC in thyroid cancer survivors treated with RAI is not increased compared with thyroid cancer survivors not treated with RAI.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 17914
Age Range See abstract
Condition See abstract

MeSH Terms

  • Breast Neoplasms
  • Humans
  • Iodine Radioisotopes
  • Neoplasms, Radiation-Induced
  • Neoplasms, Second Primary
  • Risk
  • Thyroid Neoplasms

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: iodine

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09