Determining the Role of Thiamine Deficiency in Systolic Heart Failure: A Meta-Analysis and Systematic Review

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#age-distribution #aged #aged-80-and-over #case-control-studies #comorbidity

Determining the Role of Thiamine Deficiency in Systolic Heart Failure: A Meta-Analysis and Systematic Review

Jain et al., 2015 | J Card Fail | Meta Analysis

Citation

Jain Ankur, Mehta Raj, ... Winchester David E. Determining the Role of Thiamine Deficiency in Systolic Heart Failure: A Meta-Analysis and Systematic Review. J Card Fail. 2015-Dec;21(12):1000-7. doi:10.1016/j.cardfail.2015.10.005

Abstract

BACKGROUND: Approximately 5.7 million Americans carry the diagnosis of systolic heart failure (HF), a major health care burden. HF is a known manifestation of thiamine deficiency (TD). HF patients are at unique risk for developing TD, which may contribute to further altered cardiac function and symptoms. METHODS AND RESULTS: We performed a systematic review of the literature and a meta-analysis to evaluate the prevalence of TD in HF patients, risk factors for and mechanisms of development of TD in HF population, and outcomes of thiamine supplementation in HF patients. We found 54 studies that met our selection criteria, 9 of which were suitable for meta-analysis. TD is more common in HF patients than control subjects (odds ratio 2.53, 95% confidence interval 1.65-3.87). Diuretic use, changes in dietary habits, and altered thiamine absorption and metabolism were identified as possible mechanisms of TD in HF patients. Small observational studies and randomized control trials suggest that thiamine supplementation in HF population may improve ejection fraction and reduce symptoms. CONCLUSIONS: Thiamine deficiency is more prevalent in the HF population, and its supplementation may be beneficial. The therapeutic role of thiamine in HF warrants further study.

Key Findings

We performed a systematic review of the literature and a meta-analysis to evaluate the prevalence of TD in HF patients, risk factors for and mechanisms of development of TD in HF population, and outcomes of thiamine supplementation in HF patients. We found 54 studies that met our selection criteria, 9 of which were suitable for meta-analysis. TD is more common in HF patients than control subjects (odds ratio 2.53, 95% confidence interval 1.65-3.87). Diuretic use, changes in dietary habits, and a

Outcomes Measured

  • systolic blood pressure

Population

Field Value
Population See abstract
Sample Size 54
Age Range See abstract
Condition deficiency

MeSH Terms

  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Comorbidity
  • Female
  • Heart Failure, Systolic
  • Humans
  • Male
  • Middle Aged
  • Observational Studies as Topic
  • Prevalence
  • Prognosis
  • Risk Assessment
  • Severity of Illness Index
  • Sex Distribution
  • Survival Analysis
  • Thiamine
  • Thiamine Deficiency
  • Ultrasonography

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: thiamine-heart

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09