Association between dietary vitamin C intake and risk of esophageal cancer: A dose-response meta-analysis

source extracted confidence: high 2026-04-09
#ascorbic-acid #diet #dose-response-relationship-drug #esophageal-neoplasms #humans

Association between dietary vitamin C intake and risk of esophageal cancer: A dose-response meta-analysis

Bo et al., 2016 | Int J Cancer | Meta Analysis

Citation

Bo Yacong, Lu Yan, ... Lu Quanjun. Association between dietary vitamin C intake and risk of esophageal cancer: A dose-response meta-analysis. Int J Cancer. 2016-Apr-15;138(8):1843-50. doi:10.1002/ijc.29838

Abstract

While several epidemiological studies have investigated the association between vitamin C and risk of esophageal cancer, the results remain inconsistent. In the present study, a meta-analysis was conducted to assess the impact of dietary vitamin C intake on esophageal cancer risk. Online databases were searched up to March 29, 2015, for studies on the association between dietary vitamin C intake and esophageal cancer risk. Pooled risk ratios (RRs) or odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Dose-response analyses were performed using the method of restricted cubic splines with four knots at percentiles of 5, 35, 65 and 95% of the distribution. Publication bias was estimated using Egger's tests and funnel plots. In all, 15 articles were included in this meta-analysis, including 20 studies, containing 7063 controls and 3955 cases of esophageal cancer. By comparing the highest vs. the lowest categories of vitamin C intake, we found that vitamin C was inversely associated with the risk of esophageal cancer [overall OR = 0.58, 95% CI = 0.49-0.68, I(2) = 56%]. A linear dose-response relationship was found. With an increase in dietary vitamin C intake of 50 mg/day, the risk of esophageal cancer statistically decreased by 13% (OR = 0.87, 95% CI = 0.80-0.93, p(linearity) = 0.0002). In conclusion, our analysis suggested that the higher intake of dietary vitamin C might have a protective effect against esophageal cancer.

Key Findings

In conclusion, our analysis suggested that the higher intake of dietary vitamin C might have a protective effect against esophageal cancer.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 20
Age Range See abstract
Condition See abstract

MeSH Terms

  • Ascorbic Acid
  • Diet
  • Dose-Response Relationship, Drug
  • Esophageal Neoplasms
  • Humans
  • Odds Ratio
  • Risk Factors
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't
  • Vertical: vitamin-c-cancer

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09