Effects of calcium supplementation on biomarkers of inflammation and oxidative stress in colorectal adenoma patients: a randomized controlled trial

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#adenoma #adult #aged #anti-inflammatory-agents-non-steroidal #anticarcinogenic-agents

Effects of calcium supplementation on biomarkers of inflammation and oxidative stress in colorectal adenoma patients: a randomized controlled trial

Yang et al., 2015 | Cancer Prev Res (Phila) | Rct

Citation

Yang Baiyu, Gross Myron D, ... Bostick Roberd M. Effects of calcium supplementation on biomarkers of inflammation and oxidative stress in colorectal adenoma patients: a randomized controlled trial. Cancer Prev Res (Phila). 2015-Nov;8(11):1069-75. doi:10.1158/1940-6207.CAPR-15-0168

Abstract

Inflammation and oxidative stress play important roles in colorectal carcinogenesis. There is strong evidence that calcium reduces risk for colorectal neoplasms, possibly through its ability to bind bile acids and prevent their colonic toxicity (which occurs via an oxidative mechanism and results in an inflammatory response). In a previously reported pilot, randomized, controlled trial among sporadic colorectal adenoma patients we found that those on 2.0 g/day of calcium, relative to those on placebo, had an estimated drop in a combined cytokine z-score of 48% (P = 0.18) over 6 months. To follow-up these promising preliminary findings, we tested the efficacy of two doses of supplemental calcium (1.0 or 2.0 g/day) relative to placebo on modulating circulating biomarkers of inflammation [C-reactive protein (CRP) and 10 cytokines] and oxidative stress (F2-isoprostanes) over a 4-month treatment period among 193 patients with previous sporadic, colorectal adenoma in a randomized, double-blinded, placebo-controlled clinical trial. The inflammation markers were measured in plasma using electrochemiluminescence detection-based immunoassays, and F2-isoprostanes were measured in plasma using gas chromatography-mass spectrometry. Over a 4-month treatment period, we found no appreciable effects of calcium on CRP, cytokines, or F2-isoprostanes (P > 0.4), overall or within strata of several major risk factors for colorectal carcinogenesis, such as body mass index and regular use of nonsteroidal anti-inflammatory drugs. Overall, our results provide no evidence that calcium supplementation favorably modulates concentrations of circulating biomarkers of inflammation or oxidative stress over 4 months among patients with a previous colorectal adenoma.

Key Findings

Overall, our results provide no evidence that calcium supplementation favorably modulates concentrations of circulating biomarkers of inflammation or oxidative stress over 4 months among patients with a previous colorectal adenoma.

Outcomes Measured

  • C-reactive protein
  • inflammatory markers

Population

Field Value
Population previous sporadic
Sample Size 193
Age Range See abstract
Condition stress

MeSH Terms

  • Adenoma
  • Adult
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticarcinogenic Agents
  • Biomarkers
  • Calcium, Dietary
  • Chromatography, Gas
  • Colorectal Neoplasms
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Humans
  • Immunoassay
  • Inflammation
  • Male
  • Mass Spectrometry
  • Middle Aged
  • Oxidative Stress

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
  • Vertical: calcium-colorectal

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09