Non-anaemic iron deficiency - a disease looking for recognition of diagnosis: a systematic review

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#clinical-studies-as-topic #diagnosis-differential #dietary-supplements #female #ferritins

Non-anaemic iron deficiency - a disease looking for recognition of diagnosis: a systematic review

Pratt et al., 2016 | Eur J Haematol | Meta Analysis

Citation

Pratt Jeremy J, Khan Khalid S. Non-anaemic iron deficiency - a disease looking for recognition of diagnosis: a systematic review. Eur J Haematol. 2016-Jun;96(6):618-28. doi:10.1111/ejh.12645

Abstract

OBJECTIVE: To capture all data meeting a rigid definition of non-anaemic iron deficiency (NAID) and determine whether it is associated with poor outcomes compared with normal iron status and whether iron supplementation improves outcomes in NAID. DESIGN: Systematic review. DATA SOURCES: EMBASE, Medline, Web of Science, clinicaltrials.gov, International Clinical Trials Registry Platform (ICTRP) and Central from database inception to April 2014. ELIGIBILITY CRITERIA: Ferritin <16 μg/L (<12 μg/L if age <5 yr) in the absence of anaemia in observational studies or randomised trials. Where populations were deemed to be sufficiently similar, meta-analysis was undertaken. RESULTS: There were 21 studies included. NAID in pregnancy associated with reduction in birthweight (P = 0.028). Iron supplementation in NAID was associated with improvement in objective scores (P = 0.005) and self-rating (P = 0.03) of fatigue. Meta-analysis was limited and, where possible, was not statistically significant including the comparison of NAID with cardiovascular function in adults (VO2max P = 0.21, RERmax P = 0.68), educational attainment in children (P = 0.14), infant mental (P = 0.29) and psychomotor (P = 0.07) development, and iron supplementation in NAID with educational attainment in language (P = 0.31). CONCLUSIONS: There is emerging evidence that NAID is a disease in its own right, deserving of further research in the development of strategies for detection and treatment.

Key Findings

There were 21 studies included. NAID in pregnancy associated with reduction in birthweight (P = 0.028). Iron supplementation in NAID was associated with improvement in objective scores (P = 0.005) and self-rating (P = 0.03) of fatigue. Meta-analysis was limited and, where possible, was not statistically significant including the comparison of NAID with cardiovascular function in adults (VO2max P = 0.21, RERmax P = 0.68), educational attainment in children (P = 0.14), infant mental (P = 0.29) and

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 21
Age Range See abstract
Condition deficiency

MeSH Terms

  • Clinical Studies as Topic
  • Diagnosis, Differential
  • Dietary Supplements
  • Female
  • Ferritins
  • Humans
  • Iron
  • Iron Deficiencies
  • Male
  • Phenotype
  • Pregnancy

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: iron

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09