Myo-inositol vs. D-chiro inositol in PCOS treatment

source extracted confidence: high 2026-04-09
#acne-vulgaris #adult #double-blind-method #female #hirsutism

Myo-inositol vs. D-chiro inositol in PCOS treatment

Formuso et al., 2015 | Minerva Ginecol | Rct

Citation

Formuso C, Stracquadanio M, Ciotta L. Myo-inositol vs. D-chiro inositol in PCOS treatment. Minerva Ginecol. 2015-Aug;67(4):321-5

Abstract

AIM: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women in fertile age. It is an endocrine and metabolic disorder characterized by oligo-anovulation, hyperandrogenism and insulin-resistance. Various therapeutic approaches have been attempted in PCOS, including diet and the use of pharmacological agents such as oral contraceptives (OCs) or anti-androgens. Recently, the introduction of inositol in the treatment plan has proved to be as reasonable as useful in countering the endocrine-metabolic disorders of this syndrome. METHODS: The aim of our study was to compare the clinical, endocrine and metabolic response after 6 months of therapy in 137 PCOS women characterized by oligomenorrhea and/or acne and/or mild hirsutism and insulin-resistance. The patients were treated with myo-inositol or with D-chiro-inositol or with placebo. RESULTS: Our study showed that both myo-inositol (MI-PG) and D-chiro inositol (DCI-PG) treatments are able to significantly improve the regularity of the menstrual cycle, the Acne Score, the endocrine and metabolic parameters and the insulin-resistence in young, overweight, PCOS patients. CONCLUSION: Definitely, we assumed that both treatments with myo-inositol and with D-chiro inositol could be proposed as a potential valid therapeutic approach for the treatment of patients with PCOS. Additionally, further examination and for a longer period of treatment are needed.

Key Findings

Our study showed that both myo-inositol (MI-PG) and D-chiro inositol (DCI-PG) treatments are able to significantly improve the regularity of the menstrual cycle, the Acne Score, the endocrine and metabolic parameters and the insulin-resistence in young, overweight, PCOS patients.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population pcos
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Acne Vulgaris
  • Adult
  • Double-Blind Method
  • Female
  • Hirsutism
  • Humans
  • Inositol
  • Insulin Resistance
  • Menstrual Cycle
  • Oligomenorrhea
  • Polycystic Ovary Syndrome
  • Treatment Outcome
  • Young Adult

Evidence Classification

  • Level: Rct
  • Publication Types: Comparative Study, Journal Article, Randomized Controlled Trial
  • Vertical: inositol

Provenance

  • PMID: 25670222
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-10 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-10