Vitamin E and risk of age-related cataract: a meta-analysis

source extracted confidence: high 2026-04-09
#aging #antioxidants #cataract #diet #dietary-supplements

Vitamin E and risk of age-related cataract: a meta-analysis

Zhang et al., 2015 | Public Health Nutr | Meta Analysis

Citation

Zhang Yufei, Jiang Wenjie, ... Zhang Dongfeng. Vitamin E and risk of age-related cataract: a meta-analysis. Public Health Nutr. 2015-Oct;18(15):2804-14. doi:10.1017/S1368980014003115

Abstract

OBJECTIVE: We conducted a meta-analysis to evaluate the relationship between vitamin E and age-related cataract (ARC). DESIGN: The fixed- or random-effect model was selected based on heterogeneity. Meta-regression was used to explore potential sources of between-study heterogeneity. Publication bias was evaluated using Begg's test. The dose-response relationship was assessed by a restricted cubic spline model. SETTING: Relevant studies were identified by a search of PubMed and the Cochrane Library to May 2014, without language restrictions. SUBJECTS: Studies involved samples of people of all ages. RESULTS: Dietary vitamin E intake, dietary and supplemental vitamin E intake, and high serum tocopherol levels were significantly associated with decreased risk of ARC, the pooled relative risk was 0·73 (95% CI 0·58, 0·92), 0·86 (95% CI 0·75, 0·99) and 0·77 (95% CI 0·66, 0·91), respectively. Supplemental vitamin E intake was non-significantly associated with ARC risk (relative risk=0·92; 95% CI 0·78, 1·07). The findings from dose-response analysis showed evidence of a non-linear association between dietary vitamin E intake and ARC. The risk of ARC decreased with dietary vitamin E intake from 7 mg/d (relative risk=0·94; 95% CI 0·90, 0·97). CONCLUSIONS: The findings of the meta-analysis indicated that dietary vitamin E intake, dietary and supplemental vitamin E intake, and high level of serum tocopherol might be significantly associated with reduced ARC risk.

Key Findings

Dietary vitamin E intake, dietary and supplemental vitamin E intake, and high serum tocopherol levels were significantly associated with decreased risk of ARC, the pooled relative risk was 0·73 (95% CI 0·58, 0·92), 0·86 (95% CI 0·75, 0·99) and 0·77 (95% CI 0·66, 0·91), respectively. Supplemental vitamin E intake was non-significantly associated with ARC risk (relative risk=0·92; 95% CI 0·78, 1·07). The findings from dose-response analysis showed evidence of a non-linear association between dieta

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Aging
  • Antioxidants
  • Cataract
  • Diet
  • Dietary Supplements
  • Humans
  • Tocopherols
  • Vitamin E
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review
  • Vertical: vitamin-e-eye

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09