Non-glutamatergic clozapine augmentation strategies: a review and meta-analysis

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#antidepressive-agents #antipsychotic-agents #brief-psychiatric-rating-scale #clozapine #double-blind-method

Non-glutamatergic clozapine augmentation strategies: a review and meta-analysis

Veerman et al., 2014 | Pharmacopsychiatry | Meta Analysis

Citation

Veerman S R T, Schulte P F J, ... de Haan L. Non-glutamatergic clozapine augmentation strategies: a review and meta-analysis. Pharmacopsychiatry. 2014-Nov;47(7):231-8. doi:10.1055/s-0034-1385930

Abstract

Persistent negative symptoms and cognitive impairment are major clinical problems in the treatment of schizophrenia. There is no convincing evidence regarding the efficacy of augmentation of clozapine with a second antipsychotic, ethyl eicosapentaenoic acid (E-EPA), an antidepressant, a mood stabilizer or extract of Ginkgo biloba in clozapine-resistant schizophrenia. We present an overview of studies in which the potential clinical utility of the addition of non-glutamatergic agents to clozapine is assessed. We performed a meta-analysis on the efficacy of both risperidone and aripiprazole compared to placebo. We compared the effects of the addition of a second antipsychotic or an antidepressant to clozapine on positive, negative, overall and affective symptoms of schizophrenia in double-blind placebo-controlled trials.

Key Findings

We compared the effects of the addition of a second antipsychotic or an antidepressant to clozapine on positive, negative, overall and affective symptoms of schizophrenia in double-blind placebo-controlled trials.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition mood

MeSH Terms

  • Antidepressive Agents
  • Antipsychotic Agents
  • Brief Psychiatric Rating Scale
  • Clozapine
  • Double-Blind Method
  • Drug Therapy, Combination
  • Drug Tolerance
  • Eicosapentaenoic Acid
  • Ginkgo biloba
  • Humans
  • Plant Preparations
  • Randomized Controlled Trials as Topic
  • Schizophrenia

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Review
  • Vertical: ginkgo

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09