Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk

source extracted confidence: high 2026-04-09
#alleles #deoxyribonucleases-type-ii-site-specific #genetic-predisposition-to-disease #humans #neoplasms

Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk

Xu et al., 2014 | Tumour Biol | Meta Analysis

Citation

Xu Yeqiong, He Bangshun, ... Wang Shukui. Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Tumour Biol. 2014-May;35(5):4153-69. doi:10.1007/s13277-013-1544-y

Abstract

The vitamin D receptor (VDR) can influence cancer susceptibility through binding to vitamin D. However, the previous studies were contradictory. Therefore this meta-analysis was conducted to clarify the association between VDR polymorphisms (BsmI, TaqI, FokI, and ApaI) and cancer risk. One hundred twenty-six studies were enrolled through PubMed. For VDR BsmI polymorphism, significantly increased cancer risks were observed in the overall analysis. In the further stratified analysis, increased risks were observed in colorectal and skin cancer, especially in Caucasian population. However, no significant associations were observed in other VDR polymorphisms in the overall analysis. In the further subgroup analysis, increased risks were found in oral, breast, and basal cell cancer while decreased risk was found in prostate cancer in t allele carriers of TaqI polymorphism. For VDR FokI polymorphism, increased risks were found in ovarian and skin cancer while decreased risk in glioma in f allele carriers. For VDR ApaI polymorphism, increased risk was observed in basal cell cancer, especially in Asian population in a allele carriers. In conclusion, these results indicated that b allele of BamI polymorphism was a risk factor for cancer susceptibility. Meanwhile, t allele of TaqI polymorphism was a risk factor for oral, breast, and basal cell cancer and a protective factor for prostate cancer. Moreover, f allele of FokI polymorphism was a risk factor for ovarian and skin cancer and a protective factor for glioma. Finally, a allele of ApaI polymorphism was a risk factor for basal cell cancer in Asian population.

Key Findings

Finally, a allele of ApaI polymorphism was a risk factor for basal cell cancer in Asian population.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Alleles
  • Deoxyribonucleases, Type II Site-Specific
  • Genetic Predisposition to Disease
  • Humans
  • Neoplasms
  • Polymorphism, Genetic
  • Publication Bias
  • Receptors, Calcitriol
  • Risk

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-d-cancer

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09