Clinical outcomes of vitamin D deficiency and supplementation in cancer patients

source extracted confidence: high 2026-04-09
#calcifediol #cholecalciferol #dietary-supplements #dose-response-relationship-drug #humans

Clinical outcomes of vitamin D deficiency and supplementation in cancer patients

Teleni et al., 2013 | Nutr Rev | Systematic Review

Citation

Teleni Laisa, Baker Jacqueline, ... Isenring Elizabeth A. Clinical outcomes of vitamin D deficiency and supplementation in cancer patients. Nutr Rev. 2013-Sep;71(9):611-21. doi:10.1111/nure.12047

Abstract

Results of recent studies suggest that circulating levels of vitamin D may play an important role in cancer-specific outcomes. The present systematic review was undertaken to determine the prevalence of vitamin D deficiency (<25 nmol/L) and insufficiency (25-50 nmol/L) in cancer patients and to evaluate the association between circulating calcidiol (the indicator of vitamin D status) and clinical outcomes. A systematic search of original, peer-reviewed studies on calcidiol at cancer diagnosis, and throughout treatment and survival, was conducted yielding 4,706 studies. A total of 37 studies met the inclusion criteria for this review. Reported mean blood calcidiol levels ranged from 24.7 to 87.4 nmol/L, with up to 31% of patients identified as deficient and 67% as insufficient. The efficacy of cholecalciferol supplementation for raising the concentration of circulating calcidiol is unclear; standard supplement regimens of <1,000 IU D₃ /day may not be sufficient to maintain adequate concentrations or prevent decreasing calcidiol. Dose-response studies linking vitamin D status to musculoskeletal and survival outcomes in cancer patients are lacking.

Key Findings

Dose-response studies linking vitamin D status to musculoskeletal and survival outcomes in cancer patients are lacking.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 4706
Age Range See abstract
Condition deficiency

MeSH Terms

  • Calcifediol
  • Cholecalciferol
  • Dietary Supplements
  • Dose-Response Relationship, Drug
  • Humans
  • Neoplasms
  • Treatment Outcome
  • Vitamin D
  • Vitamin D Deficiency

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09