Acute effects of pomegranate extract on postprandial lipaemia, vascular function and blood pressure

source extracted confidence: high 2026-04-09
#adolescent #adult #blood-glucose #blood-pressure #cardiovascular-physiological-phenomena

Acute effects of pomegranate extract on postprandial lipaemia, vascular function and blood pressure

Mathew et al., 2012 | Plant Foods Hum Nutr | Rct

Citation

Mathew Aarati Susan, Capel-Williams Gabriella M, ... Hall Wendy L. Acute effects of pomegranate extract on postprandial lipaemia, vascular function and blood pressure. Plant Foods Hum Nutr. 2012-Dec;67(4):351-7. doi:10.1007/s11130-012-0318-9

Abstract

We investigated whether a test drink enriched in pomegranate polyphenols, consumed with a high-fat meal, can reduce postprandial lipaemia and improve vascular function and blood pressure compared to placebo. Nineteen young, healthy men completed a randomized, controlled crossover trial. The active drink (containing a pomegranate extract) was consumed during a high-fat meal (ET-DUR) or 15 min before (ET-PRE), and the placebo drink (no pomegranate extract) was consumed during the high-fat meal (CONTROL). Postprandial lipaemia was assessed by venous plasma TAG 0-2 h, and capillary plasma TAG 0-4 h. Blood pressure and digital volume pulse, to measure reflection index (DVP-RI) and stiffness index (DVP-SI), were monitored at baseline, 2 and 4 h. There was no inhibition of postprandial lipaemia by the active drink compared to CONTROL. ET-PRE caused a greater increase in the venous plasma TAG at 2 h compared to CONTROL and ET-DUR (treatment effect P = 0.001). The incremental area under the curve 0-4 h for capillary plasma TAG was not significantly different between treatments. Systolic blood pressure (SBP) increased in the ET-PRE and ET-DUR groups to a lesser extent than the CONTROL group (treatment effect P = 0.041). There were no treatment effects for DVP-RI, DVP-SI or diastolic blood pressure. In conclusion, the consumption of a single drink containing ET-rich pomegranate extract did not decrease postprandial plasma TAG concentrations, but suppressed the postprandial increase in SBP following the high-fat meal.

Key Findings

In conclusion, the consumption of a single drink containing ET-rich pomegranate extract did not decrease postprandial plasma TAG concentrations, but suppressed the postprandial increase in SBP following the high-fat meal.

Outcomes Measured

  • blood pressure
  • systolic blood pressure
  • diastolic blood pressure

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition blood pressure

MeSH Terms

  • Adolescent
  • Adult
  • Blood Glucose
  • Blood Pressure
  • Cardiovascular Physiological Phenomena
  • Cholesterol
  • Cross-Over Studies
  • Diet, High-Fat
  • Humans
  • Hydrolyzable Tannins
  • Hyperlipidemias
  • Lythraceae
  • Male
  • Plant Extracts
  • Polyphenols
  • Postprandial Period
  • Pulse
  • Single-Blind Method
  • Triglycerides
  • Young Adult

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
  • Vertical: pomegranate

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09