Multi-Link Vision stent vs. first-generation drug-eluting stents: systematic review and meta-analysis

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#chromium-alloys #coronary-stenosis #drug-eluting-stents #female #humans

Multi-Link Vision stent vs. first-generation drug-eluting stents: systematic review and meta-analysis

Testa et al., 2011 | QJM | Meta Analysis

Citation

Testa L, Latini R A, ... Bedogni F. Multi-Link Vision stent vs. first-generation drug-eluting stents: systematic review and meta-analysis. QJM. 2011-Dec;104(12):1025-34. doi:10.1093/qjmed/hcr138

Abstract

BACKGROUND: Since its introduction, the cobalt chromium alloy MULTI-LINK VISION stent (MLV) has been extensively investigated thus leading to the largest amount of data so far available for a bare metal stent. Aim and METHODS: Systematic review and meta-analysis (according to Cochrane collaboration guidelines) aiming at summarizing the real world safety and efficacy of MLV stent. Endpoints of interest were: major adverse events [(MAE) combination of overall death and non-fatal myocardial infarction, MI], and target vessel revascularization (TVR). Rate of stent thrombosis was also assessed. RESULTS: Eleven studies finally retrieved totalling 5539 patients [7 study registries, 4243 patients and 4 randomized controlled trials (RCTs) comparing MLV vs. first generation of drug-eluting stent (DES) (paclitaxel or sirolimus eluting), (RCTs) 1296 patients]. Across study registries, at a mean follow-up of 11.1 months, MLV was associated with a 5.3% risk of MAE, 3% of death, 2.3% of MI and a 9% of TVR. Risk of ST was 0.5%. Compared to first generation of DES in RCTs, at a mean follow-up of 10.5 months, MLV achieved similar results in terms of MAE, death and MI. On the other hand, MLV was associated with a double risk of TVR [OR 2.01 (1.34-3.01), P < 0.001, number needed to treat 18 (13-40)]. Overall, in stent late loss with MLV was 0.81 mm (±0.51), while the in segment late loss was 0.61 mm (±0.5). Risk of stent thrombosis was equivalent. Of note, performance of MLV in terms of safety, efficacy and risk of repeat revascularization was quite consistent across all the published studies, despite inherent differences in study design, clinical setting, complexity of the lesions and ethnicity. CONCLUSION: Compared to first-generation DES, MLV showed substantial equivalence with respect to hard clinical endpoints. Data are consistent in study registries and RCTs meaning that the overall performance of MLV is quite predictable and reproducible into the wide spectrum of clinical settings.

Key Findings

Eleven studies finally retrieved totalling 5539 patients [7 study registries, 4243 patients and 4 randomized controlled trials (RCTs) comparing MLV vs. first generation of drug-eluting stent (DES) (paclitaxel or sirolimus eluting), (RCTs) 1296 patients]. Across study registries, at a mean follow-up of 11.1 months, MLV was associated with a 5.3% risk of MAE, 3% of death, 2.3% of MI and a 9% of TVR. Risk of ST was 0.5%. Compared to first generation of DES in RCTs, at a mean follow-up of 10.5 month

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 5539
Age Range See abstract
Condition See abstract

MeSH Terms

  • Chromium Alloys
  • Coronary Stenosis
  • Drug-Eluting Stents
  • Female
  • Humans
  • Immunosuppressive Agents
  • Male
  • Myocardial Infarction
  • Myocardial Revascularization
  • Paclitaxel
  • Randomized Controlled Trials as Topic
  • Registries
  • Risk Factors
  • Sirolimus
  • Stents
  • Thrombosis
  • Treatment Outcome
  • Tubulin Modulators

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Comparative Study, Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: chromium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09