Green and black tea in relation to gynecologic cancers

source extracted confidence: high 2026-04-09
#alphapapillomavirus #animals #anticarcinogenic-agents #antineoplastic-agents-phytogenic #antiviral-agents

Green and black tea in relation to gynecologic cancers

Butler et al., 2011 | Mol Nutr Food Res | Meta Analysis

Citation

Butler Lesley M, Wu Anna H. Green and black tea in relation to gynecologic cancers. Mol Nutr Food Res. 2011-Jun;55(6):931-40. doi:10.1002/mnfr.201100058

Abstract

SCOPE: Observational studies have evaluated the relationship between green tea intake and cancers of the ovary and endometrium, but we are not aware of the published studies on green tea intake and risk of human papillomavirus (HPV)-related cancers of the cervix, vagina, or vulva. METHODS AND RESULTS: A critical review of the published literature on tea intake and risk of ovarian and endometrial cancers was conducted. In meta-analyses, we report inverse associations for green tea intake and risk of ovarian cancer (odds ratio [OR]=0.66; 95% confidence interval [CI]: 0.54, 0.80), and for green tea and risk of endometrial cancer (OR=0.78, 95% CI: 0.62, 0.98). There was no association for black tea and ovarian cancer risk (OR=0.94, 95% CI: 0.87, 1.02) and a positive association with endometrial cancer risk (OR=1.20, 95% CI: 1.05, 1.38). We summarized the experimental evidence supporting the antiviral and immunomodulatory activities of green tea catechins, and results from randomized clinical trials that demonstrated green tea catechin efficacy on treatment of cervical lesions and external genital warts. CONCLUSION: Observational data support a protective role of green tea on risk of ovarian and endometrial cancers. Observational data are needed to evaluate whether green tea reduces risk of human papillomavirus-related cancers.

Key Findings

A critical review of the published literature on tea intake and risk of ovarian and endometrial cancers was conducted. In meta-analyses, we report inverse associations for green tea intake and risk of ovarian cancer (odds ratio [OR]=0.66; 95% confidence interval [CI]: 0.54, 0.80), and for green tea and risk of endometrial cancer (OR=0.78, 95% CI: 0.62, 0.98). There was no association for black tea and ovarian cancer risk (OR=0.94, 95% CI: 0.87, 1.02) and a positive association with endometrial c

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Alphapapillomavirus
  • Animals
  • Anticarcinogenic Agents
  • Antineoplastic Agents, Phytogenic
  • Antiviral Agents
  • Camellia sinensis
  • Catechin
  • Condylomata Acuminata
  • Endometrial Neoplasms
  • Female
  • Humans
  • Immunologic Factors
  • Ovarian Neoplasms
  • Papillomavirus Infections
  • Plant Leaves
  • Precancerous Conditions
  • Risk
  • Species Specificity
  • Tea
  • Uterine Cervical Neoplasms

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
  • Vertical: green-tea

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09