Effects of short-term dutasteride and Serenoa repens on perioperative bleeding and microvessel density in patients undergoing transurethral resection of the prostate

source extracted confidence: high 2026-04-09
#aged #aged-80-and-over #azasteroids #blood-loss-surgical #dose-response-relationship-drug

Effects of short-term dutasteride and Serenoa repens on perioperative bleeding and microvessel density in patients undergoing transurethral resection of the prostate

Tuncel et al., 2009 | Scand J Urol Nephrol | Rct

Citation

Tuncel Altug, Ener Kemal, ... Atan Ali. Effects of short-term dutasteride and Serenoa repens on perioperative bleeding and microvessel density in patients undergoing transurethral resection of the prostate. Scand J Urol Nephrol. 2009;43(5):377-82. doi:10.3109/00365590903164498

Abstract

UNLABELLED: OBJECTIVE. To evaluate the effects of short term use of dutasteride and Serenoarepens before transurethral resection of the prostate (TURP) on the amount of intraoperative blood loss and microvessel density (MVD) of prostatic stromal and suburethral tissues in the patients with benign prostatic hyperplasia. PATIENTS AND METHODS: The study involved 75 male patients who planned to have a TURP. The patients were randomly divided into three groups. The control group comprised 21 patients. Group 2 comprised 27 patients who used dutasteride 5 mg/day, and group 3 comprised 27 patients who used S. repens 160 mg/day for 5 weeks before the operation. The amount of intraoperative haemorrhage was calculated. Total blood loss, total blood loss/time, total blood loss/weight of resected tissue and total blood loss/weight/time were calculated for each patient and all were recorded. Sections from the prostatic stromal and suburethral tissues were examined for suburethral and prostatic MVD. RESULTS: The total amount of intraoperative blood loss, total blood loss/time, total blood loss/weight of resected tissue, total blood loss/weight/time, serum haemoglobin level change, prostatic MVD and suburethral MVD of the groups were compared. No significant statistical differences were found between the groups for any of these variables (p > 0.05). CONCLUSIONS: Dutasteride and S. repens therapies were not superior to control in terms of the decrease in total blood loss during TURP. Moreover, MVD showed no statistical differences in the treatment groups compared with the control group.

Key Findings

The total amount of intraoperative blood loss, total blood loss/time, total blood loss/weight of resected tissue, total blood loss/weight/time, serum haemoglobin level change, prostatic MVD and suburethral MVD of the groups were compared. No significant statistical differences were found between the groups for any of these variables (p > 0.05).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population benign prostatic hyperplasia
Sample Size 21
Age Range See abstract
Condition See abstract

MeSH Terms

  • Aged
  • Aged, 80 and over
  • Azasteroids
  • Blood Loss, Surgical
  • Dose-Response Relationship, Drug
  • Dutasteride
  • Enzyme Inhibitors
  • Follow-Up Studies
  • Humans
  • Male
  • Microvessels
  • Middle Aged
  • Phytotherapy
  • Plant Preparations
  • Preoperative Care
  • Prostate
  • Prostatic Hyperplasia
  • Serenoa
  • Time Factors
  • Transurethral Resection of Prostate
  • Treatment Outcome

Evidence Classification

  • Level: Rct
  • Publication Types: Comparative Study, Journal Article, Randomized Controlled Trial
  • Vertical: saw-palmetto-prostate

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09