Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia

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#child #folic-acid #genes-neoplasm #genetic-predisposition-to-disease #humans

Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia

Koppen et al., 2010 | Br J Haematol | Meta Analysis

Citation

Koppen Ilan J N, Hermans Frederik J R, Kaspers Gertjan J L. Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. Br J Haematol. 2010-Jan;148(1):3-14. doi:10.1111/j.1365-2141.2009.07898.x

Abstract

Acute lymphoblastic leukaemia (ALL) is the most common paediatric cancer, accounting for nearly 30% of all paediatric cancers and 80% of childhood leukaemias. Polymorphisms in folate-related genes may influence the susceptibility to childhood ALL. This review summarizes the results of 14 studies that focussed on the relationship between folate-related gene polymorphisms and the susceptibility to ALL and that fulfilled certain quality criteria. The total group consisted of 729 children and 1821 adults or non age-defined patients. The results of different studies sometimes contradict each other, for which there are several possible explanations. This includes an influence of the type of population studied, because there was a difference between Asian and European study results. Based on several studies, it is plausible that polymorphisms in the MTHFR gene, 677C>T and 1298A>C, are associated with a decreased susceptibility to childhood ALL in non-Asian populations. Polymorphisms in other folate related genes (MTRR, MTR [MS], TYMS [TS], SLC19A1 [RFC1], NNMT, and SHMT1) are less clearly associated with susceptibility to ALL, and the number of included studies on this subject in this review is limited. Further investigations on the relevance of these polymorphisms need to be performed. In general, it is clear that susceptibility to (childhood) ALL is partly related to constitutional differences in folate gene polymorphisms.

Key Findings

In general, it is clear that susceptibility to (childhood) ALL is partly related to constitutional differences in folate gene polymorphisms.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 1821
Age Range See abstract
Condition See abstract

MeSH Terms

  • Child
  • Folic Acid
  • Genes, Neoplasm
  • Genetic Predisposition to Disease
  • Humans
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Polymorphism, Genetic
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Review
  • Vertical: folate

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09