Collagenous gastritis: reports and systematic review
Collagenous gastritis: reports and systematic review
Brain et al., 2009 | Eur J Gastroenterol Hepatol | Systematic Review
Citation
Brain Oliver, Rajaguru Chandima, ... Travis Simon. Collagenous gastritis: reports and systematic review. Eur J Gastroenterol Hepatol. 2009-Dec;21(12):1419-24. doi:10.1097/MEG.0b013e32832770fa
Abstract
Collagenous gastritis is a rare disorder first described in 1989. After encountering two cases, we decided to review the literature and evaluate the collagen band. A systematic review of PubMed and EMBASE databases was performed. Twenty-eight cases have been previously described and two patterns of presentations are identifiable: children or young adults (median age 12 years, range 2-22 years) presenting with symptoms attributable to the gastritis (anaemia and pain); and older adults (median age 52 years, range 35-77 years) presenting with loose stools, often associated with collagenous colitis or coeliac disease. Our two cases (one child and one adult) matched this pattern. Immunostaining of the collagen band for collagens II, III, IV and VI, and tenascin showed that the band in our cases was predominantly tenascin. In conclusion, collagenous gastritis is a rare entity whose presentation depends on the age of the patient. An autoimmune aetiology seems possible given its associations. Treatment is empirical. The 30 cases now reported show that the disorder can relapse or persist for years.
Key Findings
The 30 cases now reported show that the disorder can relapse or persist for years.
Outcomes Measured
- Requires manual extraction
Population
| Field | Value |
|---|---|
| Population | See abstract |
| Sample Size | See abstract |
| Age Range | 2-22 years |
| Condition | See abstract |
MeSH Terms
- Adolescent
- Adult
- Aged
- Anemia, Iron-Deficiency
- Child
- Child, Preschool
- Collagen
- Diarrhea
- Female
- Gastritis
- Humans
- Male
- Middle Aged
- Tenascin
- Young Adult
Evidence Classification
- Level: Systematic Review
- Publication Types: Case Reports, Journal Article, Systematic Review
- Vertical: collagen
Provenance
- PMID: 19730387
- DOI: 10.1097/MEG.0b013e32832770fa
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09