Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome
Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome
Sivaprakasapillai et al., 2009 | Metabolism | Rct
Citation
Sivaprakasapillai Brahmesh, Edirisinghe Indika, ... Kappagoda Tissa. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009-Dec;58(12):1743-6. doi:10.1016/j.metabol.2009.05.030
Abstract
This study was undertaken to determine whether grape seed extracts (GSE) that contain powerful vasodilator phenolic compounds lower blood pressure in subjects with the metabolic syndrome. The subjects were randomized into 3 groups-(a) placebo, (b) 150 mg GSE per day, and (c) 300 mg GSE per day-and treated for 4 weeks. Serum lipids and blood glucose were measured at the beginning of the study and at the end. Blood pressure was recorded using an ambulatory monitoring device at the start of the treatment period and at the end. Both the systolic and diastolic blood pressures were lowered after treatment with GSE as compared with placebo. There were no significant changes in serum lipids or blood glucose values. These findings suggest that GSE could be used as a nutraceutical in a lifestyle modification program for patients with the metabolic syndrome.
Key Findings
These findings suggest that GSE could be used as a nutraceutical in a lifestyle modification program for patients with the metabolic syndrome.
Outcomes Measured
- blood pressure
- systolic blood pressure
- diastolic blood pressure
Population
| Field | Value |
|---|---|
| Population | the metabolic syndrome |
| Sample Size | See abstract |
| Age Range | See abstract |
| Condition | blood pressure |
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- Blood Chemical Analysis
- Blood Pressure
- Cholesterol, HDL
- Cholesterol, LDL
- Diet
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Humans
- Male
- Metabolic Syndrome
- Middle Aged
- Motor Activity
- Plant Extracts
- Seeds
- Vitis
Evidence Classification
- Level: Rct
- Publication Types: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
- Vertical: grape-seed
Provenance
- PMID: 19608210
- DOI: 10.1016/j.metabol.2009.05.030
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09