Genistein effects on quantitative ultrasound parameters and bone mineral density in osteopenic postmenopausal women

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#absorptiometry-photon #aged #bone-density #bone-density-conservation-agents #calcaneus

Genistein effects on quantitative ultrasound parameters and bone mineral density in osteopenic postmenopausal women

Atteritano et al., 2009 | Osteoporos Int | Rct

Citation

Atteritano M, Mazzaferro S, ... Buemi M. Genistein effects on quantitative ultrasound parameters and bone mineral density in osteopenic postmenopausal women. Osteoporos Int. 2009-Nov;20(11):1947-54. doi:10.1007/s00198-009-0883-4

Abstract

UNLABELLED: This study aimed at evaluating the effects of genistein (54 mg/die) on calcaneus and phalanges ultrasound (QUS) parameters and bone mineral density in osteopenic postmenopausal women. We concluded that genistein prevented bone loss in the osteopenic postmenopausal women and improves QUS parameters at the calcaneus and phalanges. INTRODUCTION: The purpose of the study was to evaluate the effects of genistein (54 mg/die) on quantitative ultrasound (QUS) parameters of the calcaneus and hand phalange and on bone mineral density (BMD) in osteopenic postmenopausal women. METHODS: One hundred thirty-eight women (age 49-67 years) were assigned to receive genistein or placebo. Bone status was assessed by measuring the anteroposterior lumbar spine and femoral neck BMD by dual energy X-ray absorptiometry and by ultrasound of the calcaneus (Achilles Plus, GE, Lunar) and of the phalanges (Bone Profiler. IGEA) at baseline and after a 1- and 2-year treatment. RESULTS: At the end of the experimental period, genistein had significantly increased BMD in the femur and lumbar spine (p < 0.001). The stiffness index, amplitude-dependent speed of sound, and bone transmission time in the genistein group had increased significantly at the end of study (+5.3, p < 0.001; +3.6%, p < 0.001; +4.6, p < 0.001, respectively). CONCLUSIONS: This study confirms that genistein prevented bone loss in the osteopenic postmenopausal women and it improves the QUS parameters.

Key Findings

At the end of the experimental period, genistein had significantly increased BMD in the femur and lumbar spine (p < 0.001). The stiffness index, amplitude-dependent speed of sound, and bone transmission time in the genistein group had increased significantly at the end of study (+5.3, p < 0.001; +3.6%, p < 0.001; +4.6, p < 0.001, respectively).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range age 49-67
Condition See abstract

MeSH Terms

  • Absorptiometry, Photon
  • Aged
  • Bone Density
  • Bone Density Conservation Agents
  • Calcaneus
  • Female
  • Femur Neck
  • Finger Phalanges
  • Genistein
  • Humans
  • Lumbar Vertebrae
  • Middle Aged
  • Osteoporosis, Postmenopausal
  • Ultrasonography

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: soy

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09