Probiotic and Prebiotic Use in Early Postoperative Period of Sleeve Gastrectomy
Probiotic and Prebiotic Use in Early Postoperative Period of Sleeve Gastrectomy
NCT ID: NCT07051824 Phase: NA Status: COMPLETED Enrollment: 60 Completion: 2025-06-16
Conditions
Sleeve Gastrectomy, Gastrointestinal Symptoms, Prebiotic, Probiotic
Interventions
Probiotic and Prebiotic
Summary
This randomized controlled clinical study investigates the effects of daily synbiotic supplementation (containing Lactobacillus rhamnosus GG and partially hydrolyzed guar gum) in patients who underwent sleeve gastrectomy. 60 participants aged 18-65 with a BMI of 35 or higher were randomly assigned to intervention (n=30) and control (n=30) groups. The intervention group received a 5 g sachet daily for 12 weeks postoperatively, mixed into 200 ml of yogurt and consumed during afternoon snacks. The control group received no supplementation. Anthropometric measurements, biochemical parameters, and gastrointestinal outcomes were assessed at baseline, week 4, and week 12. The aim is to evaluate the influence of probiotic and prebiotic supplementation on gastrointestinal function and biochemical markers in the early postoperative period following bariatric surgery.
Primary Outcome
Change in Gastrointestinal Symptom Rating Scale (GSRS) Scores