MItochondrial Diabetes LOw Carb- Diet Study
MItochondrial Diabetes LOw Carb- Diet Study
NCT ID: NCT06185790 Phase: NA Status: COMPLETED Enrollment: 17 Completion: 2025-01-03
Conditions
Mitochondrial Diseases, Diabetes-Deafness Syndrome Maternally Transmitted
Interventions
LCHF diet
Summary
In daily practice, doctors and dietitians in the clinic receive many questions in general from patients with a Mitochondrial Disease (MD), and more specific whether nutritional changes can alleviate their symptoms. Mitochondrial Inherited Diabetes and Deafness (MIDD) is due to a mitochondrial mutation at the m.3243A>G locus. Nutrition is known to affect disease burden in MIDD. Which diet does this best is unknown. Very low carbohydrate high fat diets improve mitochondrial function in isolated cells and in mice. Whether it does so in people with MIDD is unknown. Therefore, the objective of the study is to explore the effect of a low carbohydrate- high fat diet (LCHF) on clinical symptoms (Goal Attainment Scaling) and gut microbiome in patients with MIDD due to the m.3243A>G mutation. A total of 20 adult patients with the above mentioned characteristics will be randomized to receive first usual care during three months (control period), followed by LCHF dietary intervention for the next three months (intervention period), or vice versa.
Primary Outcome
Goal Attainment Scaling (GAS)