Variability in Microbial Response to Dietary Fiber
Variability in Microbial Response to Dietary Fiber
NCT ID: NCT06023940 Phase: NA Status: COMPLETED Enrollment: 30 Completion: 2023-10-31
Conditions
Microbial Colonization
Interventions
High fiber
Summary
The goal of this clinical trial is to understand varying in responses to different dietary patterns in healthy people who are getting a health screening colonoscopy.
The main questions it aims to answer are:
- What is the variability in the change of the microbes in the gut of (1) a provided diet that is high in fiber vs (2) a diet of the participant's choice.
- What is the magnitude of fasting changes in glucose and lipids following the short-term, high-fiber feeding period and identify candidate predictive factors (short-chain fatty acids, BMI, sex, starting glucose level) for these changes
Participants will be in one of two groups:
- High-fiber diet group: These participants will have a series of measurements that include: blood biochemistries, body composition measured via DEXA, anthropometrics, surveys and questionnaires, and collection of fecal samples.
- Normal diet group: These participants will eat a diet that is of their choosing (ad libitum) and will have a series of measurements that include: fecal samples, and questionnaires/surveys including food records.
Primary Outcome
Variability in microbial composition as measured by 'alpha diversity'