NiPPeR Randomised Trial - Child Follow Up Study
NiPPeR Randomised Trial - Child Follow Up Study
NCT ID: NCT05934422 Phase: NA Status: COMPLETED Enrollment: 461 Completion: 2025-08-14
Conditions
Obesity, Childhood, Cognition, Neurobehavioral Manifestations, Metabolic Disturbance, Growth Disorders, Allergy, Atopic Dermatitis, Atopy, Nutrition, Healthy, Lifestyle, Microbial Colonization, Breastfeeding
Interventions
Intervention (Study Nutritional Drink), Control (Standard Nutritional Drink)
Summary
There is an increasing focus on the need to optimise nutrition, lifestyle and metabolism of parents before and during pregnancy and of the infant after birth, but as yet there is limited understanding of the specific influences and of the underlying mechanisms.
This study is a follow up of children from the NiPPeR trial of a nutritional drink enriched with micronutrients, myo-inositol and probiotics taken preconception and during pregnancy. In this setting we will examine the influence of parental nutrition, lifestyle and metabolism before and during pregnancy on child growth, development and well-being; ascertaining growth, adiposity, metabolism, neurobehavioural and health outcomes in the children, and characterising the underlying mechanisms.
The data collected will allow identification of the contributions of parental and offspring characteristics, nutritional, lifestyle and medical factors, social and economic status, ethnicity, genetics, metabolism and microbes to promoting healthy growth, body composition and wellbeing in the children.
Primary Outcome
Child Body Mass Index (kg/m2), derived from weight and height