Probiotic Supplementation and Pancreatic β-Cell Function in Type 2 Diabetes
Probiotic Supplementation and Pancreatic β-Cell Function in Type 2 Diabetes
NCT ID: NCT05765292 Phase: NA Status: COMPLETED Enrollment: 68 Completion: 2021-12-15
Conditions
Type2 Diabetes, Obesity, Insulin Resistance, Obesity, Abdominal
Interventions
Probiotic, Placebo
Summary
Probiotics have beneficial effect on obesity related disorders in animal models. Current understanding for the beneficial effects of probiotics in type 2 diabetes strictly relies on animal and clinical data, which mainly focus on their impact on insulin resistance, anthropometric parameters, glycemic control and markers of chronic systemic inflammation. From the other hand, there is a lack of evidence-based probiotic efficacy on pancreatic β-cell function in terms of type 2 diabetes and related metabolic disorders. In this double-blind single center randomized clinical trial, effect of alive multistrain probiotic vs. placebo on pancreatic β-cell function in type 2 diabetes patient will be assessed.
Primary Outcome
β-cell function (%B)