Plant Stanol Esters and Influenza Vaccination
Plant Stanol Esters and Influenza Vaccination
NCT ID: NCT05706350 Phase: NA Status: COMPLETED Enrollment: 137 Completion: 2022-12-20
Conditions
Immune Response
Interventions
Influenza vaccine, Plant stanol soft chews (2g per day), Plant stanol soft chews (3g per day), Plant stanol soft chews (4g per day), Control soft chews
Summary
Plant stanols are known to lower low-density lipoprotein cholesterol (LDL-C). However, recent studies have suggested that these compounds also beneficially influence the immune system, e.g. increasing vaccine-specific antibody titers. BMI and age have previously been negatively associated to vaccination responses. If plant stanols indeed have beneficial effects on the immune system, people with overweight or obesity and higher age might benefit from consuming plant stanols prior to receiving the influenza vaccination.
Primary Outcome
Vaccine specific IgM antibody titer