Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali
Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali
NCT ID: NCT05550909 Phase: PHASE2 Status: COMPLETED Enrollment: 100 Completion: 2023-01-26
Conditions
Malaria,Falciparum
Interventions
Artesunate-amodiaquine combination, Primaquine Phosphate, Artemether-lumefantrine, Amodiaquine
Summary
The purpose of this study is to compare the gametocytocidal and transmission reducing activity of artesunate-amodiaquine (ASAQ) and artemether-lumefantrine-amodiaquine (ALAQ) with and without a single dose of 0.25mg/kg primaquine (PQ). Outcome measures will include infectivity to mosquitoes at 2, 7 and 14 days after treatment, gametocyte density throughout follow-up, and safety measures including haemoglobin density and the frequency of adverse events.
Primary Outcome
Change in mosquito infection rate assessed through membrane feeding assays