Antibiotyping and Prevalence of Virulent Genotypes Among Helicobacter Pylori and Their Impact on Response to Therapy
Antibiotyping and Prevalence of Virulent Genotypes Among Helicobacter Pylori and Their Impact on Response to Therapy
NCT ID: NCT05444439 Phase: NA Status: COMPLETED Enrollment: 100 Completion: 2025-01-20
Conditions
H Pylori Infection
Interventions
detection of vacuolating cytotoxin A (Vac A) and cytotoxin-associated gene A (Cag A) virulent H.Pylori genotypes by polymerase chain reaction amplification(PCR) in gastric biopsies :, Culture and sensitivity of endoscopic gastric biopsies:, Histopathological examination endoscopic gastric biopsies:, Upper endoscopy, empirical H.pylori regimens, H.Pylori Ag in stool
Summary
- Detection of primary antimicrobial susceptibility and resistance of Helicobacter Pylori infection.
- Detection of resistance and virulence genes of Helicobacter Pylori infection.
- Assessment of H pylori carcinogenicity gene.
- Evaluation of outcome and efficacy of antibiotics regimen will be used in our research.
- Evaluation of effect of other factors as diet (fatty and spicy meal), drugs as NSAIDs use, antibiotics for any cause on response of H pylori to antibiotics regimen.
Primary Outcome
detection of pre treatment antibiotic culture and sensitivity test