Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Postoperative Analgesia
Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Postoperative Analgesia
NCT ID: NCT04791059 Phase: PHASE4 Status: COMPLETED Enrollment: 200 Completion: 2022-10-07
Conditions
Scoliosis Correction, Postoperative Analgesia, S-ketamine, Dexmedetomidine, Sufentanil
Interventions
S-ketamine, Dexmedetomidine, Sufentanil
Summary
Scoliosis correction surgery is followed with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and even drug tolerance. S-ketamine is the pure dextrorotatory enantiomer of ketamine with stronger analgesic effect and less side effects, but mental side effects is a major concern. Dexmedetomidine can be used as an analgesic supplement; it also improves sleep quality in postoperative patients. We hypothesize that low-dose ketamine and dexmedetomidine in combination with opioids may have synergistic effect in analgesia and reduce drug-related side effects. This study aims to explore the effect of low-dose of S-ketamine and dexmedetomidine in combination with opioids for postoperative patient-controlled intravenous analgesia in patients following scoliosis correction surgery.
Primary Outcome
Percent of patients with moderate to severe pain within 72 hours