Exercise, Milk Thistle, and Lactobacillus to Influence Plasma Bilirubin
Exercise, Milk Thistle, and Lactobacillus to Influence Plasma Bilirubin
NCT ID: NCT04717726 Phase: PHASE3 Status: COMPLETED Enrollment: 42 Completion: 2023-07-19
Conditions
Obesity
Interventions
Milk Thistle (MT), Lactobacillus Gasseri (LAC), Exercise (EX), Control (CON)
Summary
The proposed clinical trial will test our hypothesis that, during exercise, red blood cell (RBC) release of heme and catabolism to bilirubin is an essential process that mediates gene responses that reduce body fat. We will evaluate whether Milk Thistle extract or Lactobacillus Gasseri extends bilirubin circulating times to decrease body fat further. Thus we will perform a 12-week, 6-armed trial with one group performing aerobic exercise 5 times per week (EX) one group receiving a Milk Thistle extract (MT), one group receiving a lactobacillus gasseri supplement (LAC), a group receiving only a placebo (CON), and groups both exercising and receiving the MT (MT + EX) and lactobacillus and exercise (LAC + EX).
Primary Outcome
Lean mass