Management of Mild Cognitive Impairment Patients With Aloe and Crocus - BALSAM
Management of Mild Cognitive Impairment Patients With Aloe and Crocus - BALSAM
NCT ID: NCT04436614 Phase: NA Status: COMPLETED Enrollment: 100 Completion: 2019-10-30
Conditions
Mild Cognitive Impairment
Interventions
Dietary Supplement:Aloe Vera with Crocus (saffron), Dietary Supplement:Aloe Vera (simple), Dietary Supplement:Mediterranean Diet
Summary
There is accumulating evidence suggesting that Aloe vera and Crocus (saffron) may have a positive impact on conditions involving cognitive deficits, such as Mild Cognitive Impairment (MCI) and AD. More specifically, aloe vera gel contains powerful antioxidants, which belong to a large family of substances known as polyphenols. Aloe has also been proven to possess cholinergic and cognitive enhancing capabilities. Crocus is deeper studied and it shows promising results in neuroprotection against AD through various suggested mechanisms, such as the enhancement of amyloid-beta clearance in the brain and the inhibition of neurofibrillary tangles formation. For this reason, it would be interesting to study the effects of combination of Aloe Vera and Crocus . The aim of the study is to evaluate the beneficial effect of Aloe Vera and Crocus (saffron) in comparison with Aloe (simple)on patients diagnosed with mild cognitive impairment MCI.
Study Type: Interventional Study Design: Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Prevention
Primary Outcome
Neuropsychological Assessment- Measurements to Assess General Cognitive Function.