Acid-Base Balance, Metabolism and Minerals
Acid-Base Balance, Metabolism and Minerals
NCT ID: NCT04229069 Phase: NA Status: COMPLETED Enrollment: 40 Completion: 2015-12-30
Conditions
Acid-Base Balance Disorder, Metabolic Acidosis
Interventions
alkaline salt mixture, placebo
Summary
Metabolism is controlled by macro- and micronutrients. Protein-rich diets should lead to latent acidosis at tissue level with further negative implications. Food supplements with alkaline salts are available and popular pretending to prevent these changes.
Within a randomized double-blind placebo-controlled trial, the investigators tested the hypotheses 1) that a 4-week protein-rich diet induces a latent tissue acidosis and 2) an alkaline supplement can compensate this. Acid-base balance and important metabolic parameters were determined before and after 4 weeks of supplementation by peripheral blood samples, indirect calorimetry and muscle microdialysis before and after a protein-rich test meal.
Primary Outcome
Change in muscle dialysate lactate-pyruvate ratio