Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
NCT ID: NCT04111263 Phase: NA Status: COMPLETED Enrollment: 33 Completion: 2022-11-05
Conditions
Gastrointestinal Injury, Acute Mountain Sickness
Interventions
FP, Placebo, High altitude, Sea level
Summary
The aim of this randomized, crossover clinical trial is to determine the efficacy of a gut microbiota-targeted nutritional intervention containing a blend of fermentable fibers and polyphenols (FP) for mitigating increases in GI permeability, and decrements in immune function and neuropsychologic performance following rapid ascent to simulated high altitude. Fifteen healthy young adults will participate in each of three study phases that include a 14-day supplementation period in which participants will consume 1 of 2 supplement bars: placebo (PL, will be consumed during 2 phases) and FP supplementation (will be consumed during one phase only). During the final 2-d of each phase, participants will live in a hypobaric chamber under sea level or high altitude conditions.
Primary Outcome
Difference in intestinal permeability