Effects of Green Propolis Extract (EPP-AF) on Inflammation in Hemodialysis Patients.
Effects of Green Propolis Extract (EPP-AF) on Inflammation in Hemodialysis Patients.
NCT ID: NCT04072341 Phase: PHASE1 Status: COMPLETED Enrollment: 40 Completion: 2020-01-30
Conditions
Chronic Kidney Disease Requiring Chronic Dialysis
Interventions
Propolis Period (Green Propolis 250mg/day), Control Period
Summary
End-stage chronic kidney disease is associated with the condition of chronic inflammation. Patients on hemodialysis are known to be predisposed to several factors that predispose to inflammation: dialysis membranes, central venous catheters, oxidative stress, fluid overload, sodium overload, uraemic toxins. Propolis, a natural resin produced by bees from plant materials, has anti-inflammatory, immunomodulatory, and anti-oxidant properties. The aim of this study was to evaluate the impact of Brazilian green propolis extract on inflammation in hemodialysis patients.
Primary Outcome
Change in serum level of High-sensitivity C-reactive protein from baseline to end of study periods.