Neurosteroids for PTSD in Veterans
Neurosteroids for PTSD in Veterans
NCT ID: NCT03799562 Phase: PHASE2 Status: COMPLETED Enrollment: 96 Completion: 2025-07-14
Conditions
Posttraumatic Stress Disorder
Interventions
Pregnenolone, Placebo
Summary
This study seeks to determine if pregnenolone can improve symptoms of PTSD and other symptoms that commonly occur with PTSD in Iraq/Afghanistan-era Veterans. The total study duration is 10 weeks. Eligible Veterans with PTSD will receive either pregnenolone or placebo throughout the study duration and will complete mental and physical health assessments at each study visit. Eligible participants will attend 6 in-person study visits and receive several short "check-in" phone calls.
Primary Outcome
Change in Clinician Administered PTSD Scale for DSM-5 (Visit 6-Baseline)