The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction
The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction
NCT ID: NCT03679780 Phase: PHASE1 Status: COMPLETED Enrollment: 19 Completion: 2023-07-26
Conditions
Cardiovascular Diseases, Cardiovascular Risk Factor, Vasoconstriction
Interventions
BQ-788, BQ-123, L-Arginine, NG Nitro L Arginine Methyl Ester, Sodium Nitroprusside, Lactated Ringer's
Summary
The goal of the study is to examine the possible mechanisms of impaired cutaneous microvascular function through local heating along with administration of vasoconstrictors.
Primary Outcome
Vasodilatory Response to Endothelin Receptor-A/B Blockers and L-Arginine following local heating as assessed by Intradermal Microdialysis and Laser Doppler Fluxmetry