Vitamin B Complex and Diabetic Nephropathy in Type 1 Diabetes
Vitamin B Complex and Diabetic Nephropathy in Type 1 Diabetes
NCT ID: NCT03594240 Phase: PHASE3 Status: COMPLETED Enrollment: 80 Completion: 2018-04-02
Conditions
Plasma Homocysteine, HbA1c Level
Interventions
Vitamin B complex tablets (Neurorubine TM -Forte Lactab TM), Placebo
Summary
Homocysteine levels have been found elevated in T1DM patients with Diabetic nephropathy (DN) due to several causes, including dietary deficiencies. Hyperhomocysteinemia induces renal injury and is associated with increasing urinary albumin excretion(UAE). Therefore, the investigators performed a randomized-controlled trial of oral supplementation with vitamin B complex as an adjuvant therapy for nephropathy in pediatric patients with T1DM and assessed its relation to homocysteine levels, glycemic control, microalbuminuria and cystatin C as a marker of nephropathy.
Primary Outcome
Change in plasma homocysteine