Carnosine Loading and Periodized Training in MS and HC
Carnosine Loading and Periodized Training in MS and HC
NCT ID: NCT03418376 Phase: NA Status: COMPLETED Enrollment: 45 Completion: 2017-12-30
Conditions
Multiple Sclerosis, Exercise Therapy, Dietary Supplement
Interventions
Beta-alanine supplementation, Exercise intervention
Summary
Increasing evidence favours exercise therapy as an efficient tool to counteract inactivity related secondary symptoms in MS. Furthermore, exercise therapy may affect MS-associated muscle contractile and energy supply dysfunctions. So far, low to moderate intensity exercise rehabilitation has shown to induce small but consistent improvements in several functional parameters. High intensity exercise training in MS seems to further improve this. However, although results are promising, impairments in both muscle contraction and energy supply probably attenuate therapy outcome. In keeping with the above described physiological role of skeletal muscle carnosine and because muscle carnosine content may be lower in MS, the primary aim of the present project is to investigate whether carnosine loading improves exercise therapy outcome (exercise capacity, body composition) and performance in MS. If the latter hypothesis can be confirmed, muscle carnosine loading could be a novel intervention to improve exercise capacity and muscle function in this population.
Primary Outcome
VO2max