Effect of Orally Delivered Phytochemicals on Aging and Inflammation in the Skin
Effect of Orally Delivered Phytochemicals on Aging and Inflammation in the Skin
NCT ID: NCT03289832 Phase: NA Status: COMPLETED Enrollment: 25 Completion: 2019-10-23
Conditions
Healthy Adults
Interventions
Crucera-SGS, Meriva 500-SF
Summary
The objective is to determine, in a small number of participants, the protective effects of UV-induced skin erythema (reddening or "sunburn") following oral administration of sulforaphane, curcumin, or a combination of the two plant (diet)-based supplements. The investigators will be using the over-the-counter nutritional supplements Crucera-SGS and Meriva-SF to deliver the biologically stable sulforaphane precursor and a highly bioavailable formulation of curcumin. Volunteers will be challenged with UV irradiation at 2-times the minimum erythematous dose (M.E.D.) on discrete 2 cm diameter circles on the upper buttocks. Skin redness will be monitored daily using a chromometer. Biomarkers will then be evaluated in blood, urine, and skin biopsies.
Primary Outcome
Change in Erythema 1 Day After UV Exposure