Synbiotic Approach to Immunity and Metabolism in the Elderly Study
Synbiotic Approach to Immunity and Metabolism in the Elderly Study
NCT ID: NCT03168503 Phase: NA Status: COMPLETED Enrollment: 40 Completion: 2015-01
Conditions
Healthy
Interventions
LGG+Promitor™, Promitor™, LGG-PB12+Promitor™, Maltodextrin
Summary
The aging process leads to a marked decline in immune function (immunosenescence), causing a significant reduction in immune response after vaccination or infections. Dietary intervention is an attractive, safe and non-invasive way to impact on gut bacteria and subsequently the functioning of the immune system. The ability of the dietary supplementation to alter these functions can be of particular importance in those groups that have an underdeveloped, poorly functioning immune system such as infants, immuno-compromised subjects or elderly. Research over the past two decades has provided evidence that administration of probiotics (live microorganisms which, when administered in adequate amounts, confer a health benefit on the host) could enhance immune function. Lactobacilli and bifidobacteria are the most common probiotics used in humans and various strains have been shown to have immunostimulatory properties in vitro and in experimental models, these properties include modulation of cytokine production. evidence exists of the immunostimulating effects of certain probiotics and the potential to use prebiotics to increase the levels of beneficial bacteria (which are known to be reduced in elderly population). Furthermore, by providing a probiotic at the same time as a prebiotic conditions for survival are enhanced. To date, only a small number of studies conducted have been randomised and/or placebo controlled to unequivocally demonstrate efficacies.
Primary Outcome
The modulation of the gut microbiota by synbiotics and PromitorTM inflammatory/immune biomarkers