Energy for the Brain
Energy for the Brain
NCT ID: NCT03132233 Phase: NA Status: COMPLETED Enrollment: 42 Completion: 2020-01-31
Conditions
Migraine, Episodic Migraine
Interventions
Beta-hydroxybutyrate calcium and magnesium salt, placebo powder
Summary
Approx. one billion people are suffering from migraine worldwide and yet, therapeutic options are still very limited. Research suggests that changes in energy metabolism could be part of migraine pathophysiology. Ketone bodies (KB) are endogenous alternative energy substrates. Our clinical trial assesses the efficacy and safety of KB supplements in 60-90 adult migraineurs (5-14 migraine days / months) at the University Hospital Basel. The total duration of the trial is approx. 6 months, consisting of 4 weeks baseline, 12 weeks intervention with KB powder or matched placebo and 8 weeks follow-up. The primary endpoint is the change in migraine days at the end of intervention compared to baseline. Additionally, changes in gene expression, fat-, and glucose metabolism, inflammatory markers and quality of life will be examined.
Primary Outcome
Number of migraine days