Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis
Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis
NCT ID: NCT03093207 Phase: PHASE2 Status: COMPLETED Enrollment: 34 Completion: 2020-06-29
Conditions
Residual Disease, Aggressive Periodontitis
Interventions
Open flap debridement, Placebo, Omega-3 polyunsaturated fatty acids, Aspirin
Summary
The aim of this randomized controlled clinical trial of superiority will be to evaluate the effect of 3 g of omega-3 polyunsaturated fatty acids and 100 mg of aspirin daily supplementation over a period of 180 days as adjunct to surgical therapy of residual pockets from patients with generalized aggressive periodontitis. Probing depth, clinical attachment level, gingival index and concentration of microorganisms and cytokines at baseline, 3, and 6 months after the procedure will be evaluated.
Primary Outcome
Clinical Attachment Level at Baseline, 3 Months and 6 Months